Comparative Study of Neutrophil Lymphocyte Ratio (NLR) Pulmonary Tuberculosis Patients With and Without Diabetes Mellitus

Risananda Nursyahbani; James P. Simanjuntak; Eka Fitriana

doi:10.35910/icohpj.v3i0.821

Risananda Nursyahbani Department of Medical Laboratory Technology, Health Polytechnic of Jambi, Indonesia
James P. Simanjuntak Department of Medical Laboratory Technology, Health Polytechnic of Jambi, Indonesia
Eka Fitriana Department of Medical Laboratory Technology, Health Polytechnic of Jambi, Indonesia

DOI: https://doi.org/10.35910/icohpj.v3i0.821

Keywords: Pulmonary TB without DM, Pulmonary TB with DM, NLR

Abstract

Background: Tuberculosis (TB) lungs is disease infection which caused by Mycobacterium Tuberculosis (M.TB) bacteria. The risk of pulmonary TB can increase in people with diabetes mellitus (DM). The occurrence of infection is closely related to response immune. Pulmonary TB infection causes inflammation resulting in changes in the immune system in the form of an increase in the number of neutrophils (neutrophilia) and a decrease in the number of lymphocytes (lymphocytopenia). Chronic inflammation is also experienced by DM sufferers due to hyperglycemia which damages the endothelium and triggers a cellular response resulting in an increase in NLR. This study aims to determine the overview of NLR in pulmonary TB patients with DM.

Method: This type of research is descriptive research with a cross sectional approach. This research uses a convenience sampling technique. This research was conducted in month April-June 2024 with A sample of 40 TB patients without DM and TB patients with DM from several health centers center in Jambi City.

Result: The result shows the average number of NLR in pulmonary TB without DM which is 1,60 and in pulmonary TB with DM the average was 2,59. Results of Mann Whitney test with mark p-value = 0.006 (p<0.05)

Conclusion: NLR in pulmonary TB with DM is higher than NLR in pulmonary TB without DM.