Correlation Of Neutrophil Lymphocyte Ratio (NLR) And Platelet Lymphocyte Ratio (PLR) In Children With Dengue Hemorrhagic Fever (DHF) Infection In Northern Kalimantan

Guntur Ari Kusuma; Difa Wigia Hanum; Siti Sakdiah

doi:10.35910/icohpj.v5i0.1049

Guntur Ari Kusuma Medical Laboratory Technology Department, Health Polytechnic of Jambi
Difa Wigia Hanum Medical Laboratory Technology Department, Health Polytechnic of Jambi
Siti Sakdiah Medical Laboratory Technology Department, Health Polytechnic of Jambi

DOI: https://doi.org/10.35910/icohpj.v5i0.1049

Keywords: DHF, NLR, PLR

Abstract

Background: Dengue fever is a viral infection transmitted to humans through the bite of an infected mosquito. This inflammation causes active immune cells such as neutrophils, lymphocytes, and platelets. When inflammation occurs, there will be a physiological response in the form of a decrease in the number of lymphocytes and an increase in the number of neutrophils. The ratio of neutrophils and lymphocytes is also called the Neutrophil Lymphocyte Ratio (NLR). This infection also causes a decrease in platelets and lymphocytes simultaneously. This can be worsening the patient's condition. The ratio of platelets and lymphocytes is also called Platelet lymphocyte ratio (PLR). NLR and PLR are important biomarkers of inflammation in supporting the diagnosis of DHF, allowing clinicians to immediately treat DHF cases, especially in children.

Method: This study used a retrospective observational study design with a cross sectional approach. The sampling technique used in this study was total sampling. The data collection technique in this study was observation of medical record data of DHF pediatric patients. To analyze the correlation between NLR and PLR in children with DHF infection, a correlation statistical test was used

Result: The results showed that the average value of NLR is 1,187 and PLR is 1536,74. And the results of this study also show a significant correlation between NLR and PLR with the correlation coefficient showing a strong positive correlation (r > 0.70, p-value < 0.001).

Conclusion: There is a significant correlation between NLR and PLR in children with dengue infection.