The Relationship Between The Duration Of Treatment With The Ratio Of Platelets To Lymphocytes and The Ratio Of Neutrophils To Lymphocytes In Pulmonary Tuberculosis

Syayida Halifa Natasya; Rd. Mustopa; Dewi Kurniasih

doi:10.35910/icohpj.v5i0.1045

Syayida Halifa Natasya Medical Laboratory Technology Departement, Health Polytechnic of Jambi, Indonesia
Rd. Mustopa Medical Laboratory Technology Departement, Health Polytechnic of Jambi, Indonesia
Dewi Kurniasih Medical Laboratory Technology Department, Health Polytechnic of Jambi, Indonesia

DOI: https://doi.org/10.35910/icohpj.v5i0.1045

Keywords: Pulmonary Tuberculosis, Duration of Treatment, Systemic Inflammatory Response, Platelet-to-Lymphocyte

Abstract

Background: Mycobacterium tuberculosis infection triggers a systemic inflammatory response, reflected by hematological changes such as increased Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR). This study aims to determine the relationship between the duration of treatment and PLR and NLR values in pulmonary TB patients

Methods: The type of research used was descriptive research with a cross-sectional study. Data was collected to determine the Relationship between Duration of Treatment with PLR and NLR in TB Patients in Jambi City in 2025.

Results: This study found that the mean values of PLR and NLR tend to increase during the early phase of tuberculosistreatment and decrease in the advanced phase. These results are consistent with our initial hypothesis regarding the relationship between treatment phases and changes in inflammatory parameters. Laboratory analysis data, including descriptive data and PLR and NLR values based on treatment duration, were analyzed using statistical tests. Although the analysis revealed no significant association between treatment duration and PLR or NLR values in pulmonary tuberculosispatients

Conclusion: The duration of treatment does not directly influence changes in PLR and NLR levels. Several studies have also demonstrated that inflammatory parameters such as PLR and NLR can be affected by individual factors, particularly the body's immune response, which are not necessarily dependent on the length of treatment. Therefore, individual factors and other clinical conditions may substantially influence PLR and NLR parameters.